Non-Enzymatic Desymmetrization Reactions in Aqueous Media

Symmetric organic compounds are generally obtained inexpensively, and therefore they can be attractive building blocks for the total synthesis of various pharmaceuticals natural products. The drawback is that discriminating identical functional groups in symmetric difficult. Water most environmentally benign inexpensive solvent. However, successful reactions water rather limited due to hydrophobicity general. Therefore, desymmetrization aqueous media expected offer versatile strategies a variety significant compounds. This review focuses on recent progress without utilizing enzymes.